Product Information
Main Ingredients: Amlodipine Besylate
Description: This product is an off-white to light brown oval scored tablet.
Pharmacological Actions:
Pharmacodynamics Amlodipine is a voltage-dependent calcium channel blocker belonging to the dihydropyridine class. It selectively binds to L-type channels in vascular smooth muscle, cardiac muscle, and cardiac nodal tissue. The antihypertensive effect of amlodipine is mainly related to its vasodilatory effect on arteries and arterioles, with minimal effect on veins. The duration and intensity of the antihypertensive effect are dose-dependent. The binding of amlodipine to L-type calcium channels is slow, thereby avoiding reflex tachycardia caused by the activation of baroreceptors due to a rapid decrease in blood pressure. For cats with hypertension, once-daily administration of Amlodipine Besylate Chewable Tablets can significantly lower blood pressure.
Pharmacokinetics After a single dose of 0.25mg/kg in cats, amlodipine is well absorbed. The time to reach peak plasma concentration (Tmax) is 3.13±1.29h, the peak concentration (Cmax) is 21.80±2.17ng/ml, and the elimination half-life (T1/2) is 57.89±12.21h.
Indications: Used for the treatment of systemic hypertension in cats.
Dosage and Administration:
Calculated based on amlodipine. Oral administration: For cats, 0.125~0.25mg per 1kg of body weight, once daily, for 14 consecutive days. If the systolic blood pressure remains higher than 150mmHg or the reduction in blood pressure is less than 15% compared to pre-treatment, the dosage can be doubled or increased to 0.5mg per 1kg of body weight for cats. This product can be administered directly or with food.
Cat Body Weight (kg) | Initial Dosage (tablets) |
2.5~5.0 | 0.5 |
5.1~10.0 | 1 |
≥10.0 | 2 |
Adverse Reactions:
Mild and transient vomiting may occur (incidence is approximately 13%).
Mild and transient gastrointestinal disorders (such as anorexia or diarrhea), somnolence, and dehydration may occur.
In clinical trials, when healthy young adult cats were administered a dose of 0.25mg/kg, mild proliferative gingivitis was commonly observed, accompanied by a certain degree of mandibular lymph node enlargement. Discontinuation of the drug is usually not required.
Precautions:
Do not use in cats with cardiogenic shock and severe aortic stenosis.
Since amlodipine is mainly metabolized by the liver, a benefit/risk assessment by a veterinarian should be conducted when administering this product to cats with liver disease. Do not use in cats with severe hepatic insufficiency.
Do not use in cats hypersensitive to this product.
If it is necessary to extend the medication cycle of this product, a benefit/risk assessment should be conducted by a veterinarian, and systolic blood pressure should be monitored periodically during the treatment.
Administration of amlodipine may cause a decrease in blood potassium and blood chlorine, and blood potassium and blood chlorine should be monitored during the treatment. Elderly cats with hypertension and chronic kidney disease may develop hypokalemia.
The safety of this product in cats weighing less than 2.5kg and cats with heart failure has not been determined. A benefit/risk assessment by a veterinarian should be conducted when administering this product.
In studies on rodents, no teratogenicity or reproductive toxicity of this product has been found. The safety of this product during pregnancy or lactation in cats has not been determined.
The combination of amlodipine with other antihypertensive drugs may cause hypotension. Before combined use, it is recommended to measure the blood pressure of the cat and ensure that the cat has adequate water intake. However, in clinical cases of feline hypertension, there is no evidence that the combined use of amlodipine and benazepril will cause hypotension.
When amlodipine is used in combination with beta-blockers, cardioselective calcium channel blockers, and azole antifungal drugs (such as itraconazole), it can reduce myocardial contractility and contraction rate. Special attention must be paid before administering this product to cats with ventricular dysfunction.
The safety of concurrent administration of amlodipine and antiemetics dolasetron and ondansetron has not been established.
In the event of accidental overdose, reversible hypotension may occur.
This chewable tablet is a flavored tablet. To avoid accidental ingestion, it should be stored out of reach of animals.
This product may cause hypotension. To reduce the risk of accidental ingestion by children, the tablet should be removed from the blister pack immediately before administration to the animal, and any unused half tablet should be returned to the blister pack.
Persons known to be hypersensitive to this product should avoid contact with the drug and wash their hands after use.
Withdrawal Period: Not required.
Specification: Calculated by amlodipine: 1.25mg
Storage: Store tightly sealed below 30℃.
Validity: 24 months; after the blister pack is opened, the half tablet is valid for 24 hours at 25℃.