Product Information
Composition:
Imidacloprid
Indications:
For the prevention and treatment of flea infestations on cats and dogs and for the treatment of biting lice (Trichodectes canis) on dogs.
Pharmacodynamic properties:
Imidacloprid, 1-(6-Chloro-3-pyridylmethyl)-N-nitro-imidazolidin-2-ylideneamine is an ectoparasiticide belonging to a group of chloronicotinyl compounds. Chemically, it is more accurately described as a chloronicotinyl nitroguanidine.
The substance has a high affinity for the nicotinergic acetylcholine receptors in the postsynaptic region of the central nervous system (CNS). The ensuing inhibition of cholinergic transmission in insects results in paralysis and death. Due to the weak nature of the interaction with mammalian nicotinergic receptor sites and the postulated poor penetration through the blood/brain barrier in mammals, it has virtually no effect on the mammalian CNS. The minimal pharmacological activity in mammals is supported by safety studies involving systemic administration of sub-lethal doses to rabbits, mice and rats.
In further studies, in addition to the adulticide flea efficacy of imidacloprid, a larvicidal flea efficacy in the surroundings of the treated pet has been demonstrated. Larval stages in the pet’s surroundings are killed following contact with a treated animal.
Pharmacokinetic particulars:
The product is indicated for cutaneous administration. Following topical application in dogs, the solution is quickly distributed over the animal. Acute dermal studies in the rat and target animal overdose and serum kinetic studies have established that systemic absorption is very low, transient and not relevant for the clinical efficacy. This has been further demonstrated by a study in which fleas were not killed after having fed on previously treated animals once the animal’s skin and fur had been cleaned of all active material.
Dosage & Administration:
For external use only.
Hold pipette in an upright position, twist and pull off cap.
Use reversed cap to twist and remove seal from pipette.Separate the coat and place the tip of the pipette on the skin and gently squeeze to expel a portion of the contents directly onto the skin.
Dog (kg bw) | Applicable product | Method of application |
＜4kg | 0.4ml | Take one tube of this product, drop it between the shoulder blades. |
4≤＜10kg | 1.0ml | Take one tube of this product, drop it between the shoulder blades. |
10≤＜25kg | 2.5ml | Take one tube of this product, drop it between the shoulder blades. |
25≤＜40kg | 4.0ml | Take one tube of this product, drop it on the back, from the shoulder to base of the tail, bisect 3~4 points drop the product. |
≥40kg | 4.0ml | Take two tube of this product, drop it on the back, from the shoulder to base of the tail, bisect 3~4 points drop the product. |
Cat (kg bw) | Applicable product | Method of application |
＜4kg | 0.4ml | Take one tube of this product, drop it on the back of the neck |
＞4kg | 0.8 ml | Take one tube of this product, drop it on the back of the neck |
Used once, effective action can be maintained for 3-4 weeks.
Side effects:
1.The product is bitter in taste. It maybe cause salivate if the dogs licks the application site immediately after treatment. This is no need to treatment and disappears within some minutes.
2.In rare cases skin reactions such as hair loss, redness, itching and skin lesions may occur. Agitation, disorientation and, in exceptional cases, excessive salivation and nervous signs such as incoordination, tremors and depression have been reported.
Warning:
1.Do not treat unweaned puppies or kittens of less than 8 weeks of age. Do not use in animals that are known to be hypersensitive to the active substance or any of the excipients.
2.This product is for topical use and should not be administered orally.
3.Do not apply an excessive amount of solution at any one spot that could cause some of the solution to run off the side of the pets.Apply only to undamaged skin and do not allow recently treated animals to groom each other.
4.Re-infestation from emergence of new fleas in the environment may continue to occur for six weeks or longer after treatment is initiated. More than one treatment may therefore be required, depending on the level of fleas in the environment.
5.The product remains effective if the animal becomes wet, for example after swimming or exposure to heavy rain. However, in cases of frequent swimming or bathing re-treatment may become necessary, depending on the presence of fleas in the environment. In these cases do not treat more frequently than once weekly.In case of biting louse infestation, the dog should be re-examined 30 days after treatment as some animals may require a second treatment.
6.In rare cases of overdose or licking of treated fur, nervous system disorders (such as twitching, tremors, ataxia, mydriasis, miosis, lethargy) can occur. Poisoning following inadvertent oral uptake in animals is unlikely. In this event, treatment should be symptomatic under veterinary medical attention. There is no known specific antidote but administration of activated charcoal may be beneficial.
7.Care should be taken to avoid the contents of the pipette coming into contact with the eyes or mouth of the recipient animal and avoid contact of the product with the eyes or mouth.
8.Do not eat, drink or smoke during application. Wash hands thoroughly after use.Wash off any skin contamination with soap and water.People with known skin sensitivity may be particularly sensitive to this product. If the product gets into eyes accidentally, the eyes should be thoroughly flushed with water. If skin or eye irritation persists, or the product is accidentally swallowed, obtain medical attention.
9.Keep treated pets away from materials such as leather, soft furnishings, plastics, etc until site of application is completely dry as contact may damage these surfaces.
10.Do not expose children to this product: Do not store with food, beverage and animal feed
11.Unused drugs or waste packages are best placed in hazardous waste collection centers. If disposed of together with household waste, care should be taken to prevent the improper use of waste. This product can not be treated by sewage system.
Withdrawal times:
No provision
Specifications:
For Dogs: (1) 0.4ml: imidacloprid 40mg (2) 1.0ml: imidacloprid 100mg (3) 2.5ml: imidacloprid 250mg (4) 4.0ml: imidacloprid 400mg
For Cats: (1) 0.4ml: imidacloprid 40mg (2) 0.8ml: imidacloprid 80mg
Packing:(1) 2pipettes/box (2) 3pipettes/box (3) 4pipettes/box (4) 6pipettes/box
Storage: Sealed preservation
Shelf life:60 months