Pyrantel Pamoate and Praziquantel Tablets

Ingredients:

Pyrantel Pamoate, Praziquantel

Appearance:

White to slightly yellow tablets.

Pharmacological action: 

Anti-helminth drug.

Pharmacodynamics: Praziquantel is effective against all developmental stages of the major tapeworms in the feline intestine, such as Taenia vesicularis, Taenia joeyi, Dipyridium canis, Mesophorum and Echinococcus multilocularis. Praziquantel can be quickly absorbed by the parasite's body surface and evenly distributed in the parasite's body, causing changes in the permeability of the parasite's body cell membrane to calcium ions, resulting in abnormal metabolism of the parasite, and rapidly causing severe damage inside and outside the parasite's body wall , leading to contraction and paralysis of the parasite. Pyrantel is a cholinergic stimulant that acts like nicotine and causes parasite spastic paralysis through neuromuscular blockade. Pyrantel is an anti-ascaris specific component that is effective against all nematodes in cats, including Toxocara felis, Ancylostoma tuberculatus and Ancylostoma brasiliensis.

Pharmacokinetics: In all research animals, praziquantel is absorbed very rapidly and almost completely from the stomach and small intestine after oral administration, and reaches the peak plasma concentration after 0.3 to 2 hours. Praziquantel distributes very rapidly to all organs. In all study animals, C14

The half-life of labeled praziquantel and its metabolites is 2-3 hours. Praziquantel is rapidly metabolized in the liver, and the main metabolite is 4-hydroxycyclohexyl derivative of praziquantel. Praziquantel is completely eliminated in the form of its metabolites within 48 hours, of which 40% to 71% are excreted through urine and 13% to 30% are excreted through feces. Pyrantel pamoate was barely absorbed from the gastrointestinal tract in all

study animals.

Indications: 

For the treatment of mixed nematode and tapeworm infections in cats. Such as Toxocephala felis adult worm, Ancylostoma tuberculosis adult worm, Ancylostoma brasiliensis adult worm, Echinococcus multilocularis, Dipyridium canis, Taenia vesicularis, Mesophorum spp., Joy's tapeworm, etc.

Usage and dosage: 

Based on this product. Oral administration: One dose, per 4kg body weight, cat 1 tablet (equivalent to 1kg body weight, pyrantel pamoate 57.5mg, praziquantel 5mg). See the table below for details.

It can be swallowed directly or wrapped in meat or sausage for administration without fasting.

Adult cats are routinely dewormed every 3 months.

When roundworm infestation occurs, complete elimination of the roundworm cannot be guaranteed, especially in kittens. Cats/humans who come into contact with cats using this product may still be infected. Therefore, kittens should be dosed once every 14 days after the first dose until 2-3 weeks after weaning.

Adverse reactions: In rare cases, mild and transient gastrointestinal disturbances, such as increased salivation and/or vomiting, and mild and transient nerve damage, such as ataxia, may occur after using this product.

Precautions:

1. Kittens weighing less than 1kg are prohibited.

2. Since the earliest possible time for cats to be infected with tapeworms is 3 weeks of

age, this product is only suitable for cats diagnosed with mixed infections over 3 weeks of age.

3. Do not use for pregnant female cats.

4. For echinococcosis, medication, necessary follow-up examinations, and personal protection should comply with relevant regulations. Consult your local veterinarian or institute of parasitology if necessary.

5. Frequent and repeated use of the same class of anthelmintics may develop drug resistance to the entire class of substances.

6. Unused veterinary drug products or wastes of such veterinary drug products should be disposed of in accordance with regulations. If it is disposed of together with domestic waste, care should be taken to prevent improper contact with these wastes. Veterinary medicinal products shall not be disposed of together with or through the sewage system.

7. Wash hands after administration.

8. Keep out of reach of children.

Withdrawal period: no need to formulate

Specifications: 0.339g: Pyrantel Pamoate 0.23g+Praziquantel 0.02g

Storage: Store at room temperature.

Shelf life: 2 years.